In aging research, evidence emerges that aging is controlled by genetic mechanisms involving signal transduction pathways highly conserved from yeast to mammals. Hyper-stimulation of certain signaling pathways drives the aging process and is involved in cell senescence and age-related disease. Modulation of DNA-damage response, sirtuins and stress-response, insulin-activated pathways, nutrient-sensing pathways, p53, FOXO and PTEN extends life span. And calorie restriction extends life span by modulating the same signaling pathways. This provides a potential means of pharmacologic intervention to extend life span and treat age-related diseases. This new journal welcomes scientists in all disciplines, not only those in traditional gerontology.
|Journal Title||:||AGING Journal|
|Coverage||:||2009 to Present|
|Impact Factor 2013||:||4.696|
|Impact Factor 2014||:||Calculating|
|5-Year Impact Factor||:||4.625|